ea0008p29 | Diabetes, metabolism and cardiovascular | SFE2004
Gnanalingham MG
, Gopalakrishnan GS
, Mostyn A
, Dandrea J
, Symonds ME
, Stephenson T
Increases in proinflammatory pathways and macrophages in adipose tissue (AT) have been implicated in the metabolic complications of obesity (1). Nutrient-restriction (NR) in early to mid gestation reduces maternal plasma cortisol and increases fetal AT (2). Uncoupling protein (UCP)-2 is genetically linked to obesity and type 2 diabetes, and has been implicated in macrophage-mediated immunity. The effect of maternal NR in early to mid and late gestation on UCP2 and glucocortico...